The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan‐induced leukopenia and oxidative stress response

BACKGROUND AND PURPOSE: Irinotecan, used in colorectal cancer therapy, is metabolized by glucuronidation involving different UDP‐glucuronosyltransferase (UGT)1A isoforms leading to facilitated elimination from the body. Individuals homozygous for the genetic variants UGT1A1*28 (Gilbert syndrome) and...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Kalthoff, Sandra, Paulusch, Stefan, Rupp, Alexander, Holdenrieder, Stefan, Hartmann, Gunther, Strassburg, Christian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443465/
https://ncbi.nlm.nih.gov/pubmed/32548889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15162
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