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Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation
The human myelogenous leukemic cell line, K562 undergoes erythroid differentiation by exposure to hemin. Here, we uncovered NSD2 as an innate erythroid differentiation-related factor through a genome-wide CRISPR library screen and explored the regulatory role of NSD2 during myeloid leukemia cell dif...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443147/ https://ncbi.nlm.nih.gov/pubmed/32826945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01186-8 |
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