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Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix

Aberrant activation of the hedgehog (Hh) signaling pathway is associated with the formation of medulloblastoma (MB), the most common malignant pediatric brain tumor. However, tumor cells from human and mouse MB can not be passaged or preserved after being adherently cultured. Moreover, Hh signaling...

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Bibliografiske detaljer
Udgivet i:Lab Invest
Main Authors: Cheng, Yan, Franco-Barraza, Janusz, Wang, Yuan, Zheng, Chaonan, Zhang, Li, Qu, Yanghui, Long, Yaqiu, Cukierman, Edna, Yang, Zeng-jie
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442735/
https://ncbi.nlm.nih.gov/pubmed/32457352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-0443-2
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