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Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix

Aberrant activation of the hedgehog (Hh) signaling pathway is associated with the formation of medulloblastoma (MB), the most common malignant pediatric brain tumor. However, tumor cells from human and mouse MB can not be passaged or preserved after being adherently cultured. Moreover, Hh signaling...

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Dades bibliogràfiques
Publicat a:Lab Invest
Autors principals: Cheng, Yan, Franco-Barraza, Janusz, Wang, Yuan, Zheng, Chaonan, Zhang, Li, Qu, Yanghui, Long, Yaqiu, Cukierman, Edna, Yang, Zeng-jie
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442735/
https://ncbi.nlm.nih.gov/pubmed/32457352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-0443-2
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