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Biomarkers associated with beneficial PD-1 checkpoint blockade in non-small-cell lung cancer (NSCLC) identified using high-plex digital spatial profiling

PURPOSE: Only a minority of patients with advanced non-small-cell lung cancer (NSCLC) truly benefit from single-agent PD-1 checkpoint blockade, and more robust predictive biomarkers are needed. EXPERIMENTAL DESIGN: We assessed tumor samples from 67 immunotherapy-treated NSCLC cases represented in a...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Zugazagoitia, Jon, Gupta, Swati, Liu, Yuting, Fuhrman, Kit, Gettinger, Scott, Herbst, Roy, Schalper, Kurt A., Rimm, David L.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442721/
https://ncbi.nlm.nih.gov/pubmed/32253229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0175
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