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Synthesis, pharmacological evaluations and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: rigidification of D(1) receptor selective 1-phenylbenzazepines and discovery of a new 5-HT(6) receptor scaffold
The novel 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework, a structurally rigidified variant of the 1-phenylbenzazepine template, was synthesized via direct arylation as a key reaction. Evaluation of the binding affinities of the rigidified compounds across a battery of serotonin, dopamine...
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| Published in: | Chem Biol Drug Des |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442682/ https://ncbi.nlm.nih.gov/pubmed/32279445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13691 |
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