AXL mediates cetuximab and radiation resistance through tyrosine 821 and the c-ABL kinase pathway in head and neck cancer

PURPOSE: Radiation and cetuximab are therapeutics used in management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these modalities, development of both intrinsic and acquired resistance is an emerging problem in the management of this disease. The purpose of this s...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: McDaniel, Nellie K, Iida, Mari, Nickel, Kwangok P, Longhurst, Colin A, Fischbach, Samantha R, Rodems, Tamara S, Kranjac, Carlene A, Bo, Amber Y, Luo, Qianyun, Gallagher, Meghan M, Welke, Noah B, Mitchell, Kaitlyn R, Schulz, Alison E, Eckers, Jaimee C, Hu, Rong, Salgia, Ravi, Hong, Seungpyo, Bruce, Justine Y, Kimple, Randall J, Wheeler, Deric L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442604/
https://ncbi.nlm.nih.gov/pubmed/32439698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3142
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