Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fzd5 determined by single-particle cryo-EM at 3.7 Å...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Tsutsumi, Naotaka, Mukherjee, Somnath, Waghray, Deepa, Janda, Claudia Y, Jude, Kevin M, Miao, Yi, Burg, John S, Aduri, Nanda Gowtham, Kossiakoff, Anthony A, Gati, Cornelius, Garcia, K Christopher
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Structural Biology and Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442489/
https://ncbi.nlm.nih.gov/pubmed/32762848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58464
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