Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fzd5 determined by single-particle cryo-EM at 3.7 Å...

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Udgivet i:eLife
Main Authors: Tsutsumi, Naotaka, Mukherjee, Somnath, Waghray, Deepa, Janda, Claudia Y, Jude, Kevin M, Miao, Yi, Burg, John S, Aduri, Nanda Gowtham, Kossiakoff, Anthony A, Gati, Cornelius, Garcia, K Christopher
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442489/
https://ncbi.nlm.nih.gov/pubmed/32762848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58464
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