Anti-α(4)β(7) monoclonal antibody–conjugated nanoparticles block integrin α(4)β(7) on intravaginal T cells in rhesus macaques

Intravenous administration of anti-α(4)β(7) monoclonal antibody in macaques decreases simian immunodeficiency virus (SIV) vaginal infection and reduces gut SIV loads. Because of potential side effects of systemic administration, a prophylactic strategy based on mucosal administration of anti-α(4)β(7...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Yang, Sidi, Arrode-Bruses, Geraldine, Frank, Ines, Grasperge, Brooke, Blanchard, James, Gettie, Agegnehu, Martinelli, Elena, Ho, Emmanuel A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2020
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442472/
https://ncbi.nlm.nih.gov/pubmed/32937372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9853
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