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Anti-α(4)β(7) monoclonal antibody–conjugated nanoparticles block integrin α(4)β(7) on intravaginal T cells in rhesus macaques
Intravenous administration of anti-α(4)β(7) monoclonal antibody in macaques decreases simian immunodeficiency virus (SIV) vaginal infection and reduces gut SIV loads. Because of potential side effects of systemic administration, a prophylactic strategy based on mucosal administration of anti-α(4)β(7...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442472/ https://ncbi.nlm.nih.gov/pubmed/32937372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9853 |
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