Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique genetic makeup, pathological heterogeneity, and brainstem location all present challenges to treatment. Developing mouse models that accurately reflect each of these distinct features will be...

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Vydáno v:Neuro Oncol
Hlavní autoři: Patel, Smruti K, Hartley, Rachel M, Wei, Xin, Furnish, Robin, Escobar-Riquelme, Fernanda, Bear, Heather, Choi, Kwangmin, Fuller, Christine, Phoenix, Timothy N
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Pediatric Neuro-Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442382/
https://ncbi.nlm.nih.gov/pubmed/31638150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz197
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