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A concise synthesis of 3-substituted-7-amino-6-carboxyl-8-azachromones
We report on an approach to truncate the tricyclic 5H-chromeno[2,3-b]pyridin-5-one core of amlexanox, an approved drug under investigation for the treatment of obesity, to the bicyclic 4H-pyrano[2,3-b]pyridin-4-one (8-azachromone) core. A short, concise synthesis generates a key intermediate with re...
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| Published in: | Tetrahedron Lett |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7442137/ https://ncbi.nlm.nih.gov/pubmed/32831416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2019.06.066 |
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