Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

T cells engineered to express chimeric antigen receptors (CAR-T cells) have shown impressive clinical efficacy in the treatment of B cell malignancies. However, the development of CAR-T cell therapies for solid tumors is hampered by the lack of truly tumor-specific antigens and poor control over T c...

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Udgivet i:Nat Commun
Main Authors: Salzer, Benjamin, Schueller, Christina M., Zajc, Charlotte U., Peters, Timo, Schoeber, Michael A., Kovacic, Boris, Buri, Michelle C., Lobner, Elisabeth, Dushek, Omer, Huppa, Johannes B., Obinger, Christian, Putz, Eva M., Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441178/
https://ncbi.nlm.nih.gov/pubmed/32820173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17970-3
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