Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients

[Image: see text] CD19 is among the most relevant targets in cancer immunotherapy. However, its extracellular domain (ECD) is prone to aggregation and misfolding, representing a major obstacle for the development and analysis of CD19-targeted therapeutics. Here, we engineered stabilized CD19-ECD (te...

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Detalhes bibliográficos
Publicado no:ACS Synth Biol
Main Authors: Laurent, Elisabeth, Sieber, Anna, Salzer, Benjamin, Wachernig, Anna, Seigner, Jacqueline, Lehner, Manfred, Geyeregger, René, Kratzer, Bernhard, Jäger, Ulrich, Kunert, Renate, Pickl, Winfried F., Traxlmayr, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155657/
https://ncbi.nlm.nih.gov/pubmed/33843201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.1c00010
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