A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

Molecular ON-switches in which a chemical compound induces protein–protein interactions can allow cellular function to be controlled with small molecules. ON-switches based on clinically applicable compounds and human proteins would greatly facilitate their therapeutic use. Here, we developed an ON-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zajc, Charlotte U., Dobersberger, Markus, Schaffner, Irene, Mlynek, Georg, Pühringer, Dominic, Salzer, Benjamin, Djinović-Carugo, Kristina, Steinberger, Peter, De Sousa Linhares, Annika, Yang, Nicole J., Obinger, Christian, Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334647/
https://ncbi.nlm.nih.gov/pubmed/32554495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911154117
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