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Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer

IKBKE is an oncogene in triple-negative breast cancer (TNBC), and we demonstrate that IKBKE small interfering RNA (siRNA) inhibits the proliferation, migration, and invasion of TNBC cells. Despite the recent success of siRNA therapeutics targeting to the liver, there still remains a great challenge...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Zhao, Zhen, Li, Yuanke, Liu, Hao, Jain, Akshay, Patel, Pratikkumar Vinodchandra, Cheng, Kun
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439402/
https://ncbi.nlm.nih.gov/pubmed/32832636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb0616
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