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Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer

IKBKE is an oncogene in triple-negative breast cancer (TNBC), and we demonstrate that IKBKE small interfering RNA (siRNA) inhibits the proliferation, migration, and invasion of TNBC cells. Despite the recent success of siRNA therapeutics targeting to the liver, there still remains a great challenge...

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Podrobná bibliografie
Vydáno v:Sci Adv
Hlavní autoři: Zhao, Zhen, Li, Yuanke, Liu, Hao, Jain, Akshay, Patel, Pratikkumar Vinodchandra, Cheng, Kun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439402/
https://ncbi.nlm.nih.gov/pubmed/32832636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb0616
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