Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Cytosine base editors (CBEs) enable efficient cytidine-to-thymidine (C-to-T) substitutions at targeted loci without double-stranded breaks. However, current CBEs edit all Cs within their activity windows, generating undesired bystander mutations. In the most challenging circumstance, when a bystande...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Lee, Sangsin, Ding, Ning, Sun, Yidi, Yuan, Tanglong, Li, Jing, Yuan, Qichen, Liu, Lizhong, Yang, Jie, Wang, Qian, Kolomeisky, Anatoly B., Hilton, Isaac B., Zuo, Erwei, Gao, Xue
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439359/
https://ncbi.nlm.nih.gov/pubmed/32832622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba1773
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