Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Ghrelin is a gastric peptide hormone with important physiological functions. The unique feature of ghrelin is its Serine 3 acyl-modification, which is essential for ghrelin’s activity. However, it remains to be elucidated why the acyl-modification of ghrelin is necessary for activity. To address the...

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Publicado en:Nat Commun
Autores principales: Shiimura, Yuki, Horita, Shoichiro, Hamamoto, Akie, Asada, Hidetsugu, Hirata, Kunio, Tanaka, Misuzu, Mori, Kenji, Uemura, Tomoko, Kobayashi, Takuya, Iwata, So, Kojima, Masayasu
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438500/
https://ncbi.nlm.nih.gov/pubmed/32814772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17554-1
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