Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias

Sphingosine-1-phosphate (S1P) regulates numerous important physiological functions, including immune response and vascular integrity, via its cognate receptors (S1PR1 to S1PR5); however, it remains unclear how S1P activates S1PRs upon binding. Here, we determined the crystal structure of the active...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Maeda, Shintaro, Shiimura, Yuki, Asada, Hidetsugu, Hirata, Kunio, Luo, Fangjia, Nango, Eriko, Tanaka, Nobuo, Toyomoto, Masayasu, Inoue, Asuka, Aoki, Junken, Iwata, So, Hagiwara, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189593/
https://ncbi.nlm.nih.gov/pubmed/34108205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf5325
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