NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitive to CHD4 amongst the NuRD members. Mechanisticall...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Marques, Joana G, Gryder, Berkley E, Pavlovic, Blaz, Chung, Yeonjoo, Ngo, Quy A, Frommelt, Fabian, Gstaiger, Matthias, Song, Young, Benischke, Katharina, Laubscher, Dominik, Wachtel, Marco, Khan, Javed, Schäfer, Beat W
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Cancer Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438112/
https://ncbi.nlm.nih.gov/pubmed/32744500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54993
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