Predicting steady‐state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable?

In previous studies, steady‐state Z‐endoxifen plasma concentrations (ENDOss) correlated with relapse‐free survival in women on tamoxifen (TAM) treatment for breast cancer. ENDOss also correlated significantly with CYP2D6 genotype (activity score) and CYP2D6 phenotype (dextromethorphan test). Our aim...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Gusella, Milena, Pasini, Felice, Corso, Barbara, Bertolaso, Laura, De Rosa, Giovanni, Falci, Cristina, Modena, Yasmina, Barile, Carmen, Da Corte Z, Donatella, Fraccon, AnnaPaola, Toso, Silvia, Cretella, Elisabetta, Brunello, Antonella, Modonesi, Caterina, Segati, Romana, Oliani, Cristina, Minicuci, Nadia, Padrini, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437348/
https://ncbi.nlm.nih.gov/pubmed/32813313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.646
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