POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East

BACKGROUND: Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic variants in well‐defined CRC predisposing genes. The frequency and effect of exonuclease domain pathogenic variants of POLE and POLD1 genes in...

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Veröffentlicht in:Mol Genet Genomic Med
Hauptverfasser: Siraj, Abdul K., Bu, Rong, Iqbal, Kaleem, Parvathareddy, Sandeep K., Masoodi, Tariq, Siraj, Nabil, Al‐Rasheed, Maha, Kong, Yan, Ahmed, Saeeda O., Al‐Obaisi, Khadija A. S., Victoria, Ingrid G., Arshad, Maham, Al‐Dayel, Fouad, Abduljabbar, Alaa, Ashari, Luai H., Al‐Kuraya, Khawla S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434734/
https://ncbi.nlm.nih.gov/pubmed/32567205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.1368
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