POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East

BACKGROUND: Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic variants in well‐defined CRC predisposing genes. The frequency and effect of exonuclease domain pathogenic variants of POLE and POLD1 genes in...

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Библиографические подробности
Опубликовано в: :Mol Genet Genomic Med
Главные авторы: Siraj, Abdul K., Bu, Rong, Iqbal, Kaleem, Parvathareddy, Sandeep K., Masoodi, Tariq, Siraj, Nabil, Al‐Rasheed, Maha, Kong, Yan, Ahmed, Saeeda O., Al‐Obaisi, Khadija A. S., Victoria, Ingrid G., Arshad, Maham, Al‐Dayel, Fouad, Abduljabbar, Alaa, Ashari, Luai H., Al‐Kuraya, Khawla S.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434734/
https://ncbi.nlm.nih.gov/pubmed/32567205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.1368
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