3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting colorectal cancer and other malignancies associated...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Badder, Luned M., Hollins, Andrew J., Herpers, Bram, Yan, Kuan, Ewan, Kenneth B., Thomas, Mairian, Shone, Jennifer R., Badder, Delyth A., Naven, Marc, Ashelford, Kevin E., Hargest, Rachel, Clarke, Alan R., Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S., Shaw, Paul H., Dale, Trevor C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433887/
https://ncbi.nlm.nih.gov/pubmed/32810173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235319
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