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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications†

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conju...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: LeValley, Paige J., Ovadia, Elisa M., Bresette, Christopher A., Sawicki, Lisa A., Maverakis, Emanual, Bai, Shi, Kloxin, April M.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433322/
https://ncbi.nlm.nih.gov/pubmed/29863200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03218a
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