Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1

[Image: see text] Cell–cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs through complex modes for which there are few representa...

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Gepubliceerd in:ACS Pharmacol Transl Sci
Hoofdauteurs: Bumbak, Fabian, Thomas, Trayder, Noonan-Williams, Billy J., Vaid, Tasneem M., Yan, Fei, Whitehead, Alice R., Bruell, Shoni, Kocan, Martina, Tan, Xuan, Johnson, Margaret A., Bathgate, Ross A. D., Chalmers, David K., Gooley, Paul R., Scott, Daniel J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432660/
https://ncbi.nlm.nih.gov/pubmed/32832871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00026
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