High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II

We recently developed a blood–brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and demonstrated its ability to reduce glycosaminoglycan (GAG) accumulation in the brains of a mouse model of mucopolysaccharidosis (MPS) II. To...

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Publicat a:Int J Mol Sci
Autors principals: Wang, Junhua, Bhalla, Akhil, Ullman, Julie C., Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L., Skuja, Lukas L., Dugas, Jason C., Davis, Sonnet S., Poda, Suresh B., Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K., Henry, Anastasia G., Harris, Jeffrey M., Henne, Kirk R., Astarita, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432392/
https://ncbi.nlm.nih.gov/pubmed/32751752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155449
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