Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Levodopa (L-DOPA) treatment is the main gold-standard therapy for Parkinson disease (PD). Besides good antiparkinsonian effects, prolonged use of this drug is associated to the development of involuntary movements known as L-DOPA-induced dyskinesia (LID). L-DOPA-induced dyskinesia is linked to a sen...

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Bibliografiske detaljer
Udgivet i:Front Aging Neurosci
Main Authors: Calabrese, Valeria, Di Maio, Anna, Marino, Gioia, Cardinale, Antonella, Natale, Giuseppina, De Rosa, Arianna, Campanelli, Federica, Mancini, Maria, Napolitano, Francesco, Avallone, Luigi, Calabresi, Paolo, Usiello, Alessandro, Ghiglieri, Veronica, Picconi, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431470/
https://ncbi.nlm.nih.gov/pubmed/32848709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00230
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