ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expressi...

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Udgivet i:medRxiv
Main Authors: El-Sayed Moustafa, Julia S., Jackson, Anne U., Brotman, Sarah M., Guan, Li, Villicaña, Sergio, Roberts, Amy L., Zito, Antonino, Bonnycastle, Lori, Erdos, Michael R., Narisu, Narisu, Stringham, Heather M., Welch, Ryan, Yan, Tingfen, Lakka, Timo, Parker, Stephen, Tuomilehto, Jaakko, Collins, Francis S., Pajukanta, Päivi, Boehnke, Michael, Koistinen, Heikki A., Laakso, Markku, Falchi, Mario, Bell, Jordana T., Scott, Laura J., Mohlke, Karen L., Small, Kerrin S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430606/
https://ncbi.nlm.nih.gov/pubmed/32817962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.11.20171108
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