Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

A safe, effective, and scalable vaccine is urgently needed to halt the ongoing SARS-CoV-2 pandemic. Here, we describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle vaccin...

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Publicado no:bioRxiv
Main Authors: Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430571/
https://ncbi.nlm.nih.gov/pubmed/32817941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.11.247395
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