Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle vaccines display 60 S...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Guerriero, Kathryn, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604136/
https://ncbi.nlm.nih.gov/pubmed/33160446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.10.043
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados