Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle vaccines display 60 S...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell
Hlavní autoři: Walls, Alexandra C., Fiala, Brooke, Schäfer, Alexandra, Wrenn, Samuel, Pham, Minh N., Murphy, Michael, Tse, Longping V., Shehata, Laila, O’Connor, Megan A., Chen, Chengbo, Navarro, Mary Jane, Miranda, Marcos C., Pettie, Deleah, Ravichandran, Rashmi, Kraft, John C., Ogohara, Cassandra, Palser, Anne, Chalk, Sara, Lee, E-Chiang, Guerriero, Kathryn, Kepl, Elizabeth, Chow, Cameron M., Sydeman, Claire, Hodge, Edgar A., Brown, Brieann, Fuller, Jim T., Dinnon, Kenneth H., Gralinski, Lisa E., Leist, Sarah R., Gully, Kendra L., Lewis, Thomas B., Guttman, Miklos, Chu, Helen Y., Lee, Kelly K., Fuller, Deborah H., Baric, Ralph S., Kellam, Paul, Carter, Lauren, Pepper, Marion, Sheahan, Timothy P., Veesler, David, King, Neil P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604136/
https://ncbi.nlm.nih.gov/pubmed/33160446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.10.043
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky