Intratumoral TIGIT(+) CD8(+) T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer

BACKGROUND: T-cell immunoglobulin and ITIM domain (TIGIT) is identified as a novel checkpoint receptor that can facilitate immune escape via mediating T-cell exhaustion in tumors. However, the clinical significance and immune contexture correlation of intratumoral TIGIT(+) CD8(+) T-cells remain to b...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Liu, Zhaopei, Zhou, Quan, Wang, Zewei, Zhang, Hongyu, Zeng, Han, Huang, Qiuren, Chen, Yifan, Jiang, Wenbin, Lin, Zhiyuan, Qu, Yang, Xiong, Ying, Bai, Qi, Xia, Yu, Wang, Yiwei, Liu, Li, Zhu, Yu, Xu, Le, Dai, Bo, Guo, Jianming, Wang, Jiajun, Chang, Yuan, Zhang, Weijuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430558/
https://ncbi.nlm.nih.gov/pubmed/32817209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000978
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