Intratumoral CXCL13(+)CD8(+)T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

BACKGROUND: Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4(+)T cells (T(FH)) and a contributor to tertiary lymphoid structures (TLS). Although secretion and function of CXCL13 produced by T(FH) have been deeply explored,...

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Bibliografske podrobnosti
izdano v:J Immunother Cancer
Main Authors: Dai, Siyuan, Zeng, Han, Liu, Zhaopei, Jin, Kaifeng, Jiang, Wenbin, Wang, Zewei, Lin, Zhiyuan, Xiong, Ying, Wang, Jiajun, Chang, Yuan, Bai, Qi, Xia, Yu, Liu, Li, Zhu, Yu, Xu, Le, Qu, Yang, Guo, Jianming, Xu, Jiejie
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2021
Teme:
Immunotherapy Biomarkers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887366/
https://ncbi.nlm.nih.gov/pubmed/33589528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001823
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