Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF

Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocat...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wang, Chongcheng, He, Chuan, Lu, Shan, Wang, Xuanzhong, Wang, Lei, Liang, Shipeng, Wang, Xinyu, Piao, Meihua, Cui, Jiayue, Chi, Guangfan, Ge, Pengfei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429844/
https://ncbi.nlm.nih.gov/pubmed/32801360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02866-3
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