Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis

Apoptosis is an essential step in cavitation during embryonic epithelial morphogenesis, but its mechanisms are largely unknown. In this paper, we used embryonic stem cell–differentiated embryoid bodies (EBs) as a model and found that Bnip3 (Bcl-2/adenovirus E1B 19-kD interacting protein), a BH3-only...

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Main Authors: Qi, Yanmei, Tian, Xiaoxiang, Liu, Jie, Han, Yaling, Graham, Alan M., Simon, M. Celeste, Penninger, Josef M., Carmeliet, Peter, Li, Shaohua
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392936/
https://ncbi.nlm.nih.gov/pubmed/22753893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201111063
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