PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation

The tumor suppressor phosphatase and tensin homolog (PTEN) dephosphorylates PIP3 and antagonizes the prosurvival PI3K-Akt pathway. Targeted deletion of PTEN in mice led to early embryonic lethality. To elucidate its role in embryonic epithelial morphogenesis and the underlying mechanisms, we used em...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Qi, Y, Liu, J, Saadat, S, Tian, X, Han, Y, Fong, G-H, Pandolfi, P P, Lee, L Y, Li, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392082/
https://ncbi.nlm.nih.gov/pubmed/25394489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.185
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