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Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification
A series of vancomycin C-terminus guanidine modifications are disclosed that improve antimicrobial activity, enhance the durability of antimicrobial action against selection or induction of resistance, and introduce a synergistic mechanism of action independent of D-Ala-D-Ala binding and inhibition...
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| Publié dans: | ACS Infect Dis |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7429263/ https://ncbi.nlm.nih.gov/pubmed/32598127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00258 |
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