Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

BACKGROUND: Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation of lipid peroxidation products acrolein and 4‐hydroxy trans‐2‐nonenal, and the depletion of ATP levels. Cardioprotective interventions, desig...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Zhao, Jingjing, Conklin, Daniel J., Guo, Yiru, Zhang, Xiang, Obal, Detlef, Guo, Luping, Jagatheesan, Ganapathy, Katragadda, Kartik, He, Liqing, Yin, Xinmin, Prodhan, Md Aminul Islam, Shah, Jasmit, Hoetker, David, Kumar, Amit, Kumar, Vijay, Wempe, Michael F., Bhatnagar, Aruni, Baba, Shahid P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429021/
https://ncbi.nlm.nih.gov/pubmed/32515247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015222
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