Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

BACKGROUND: Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation of lipid peroxidation products acrolein and 4‐hydroxy trans‐2‐nonenal, and the depletion of ATP levels. Cardioprotective interventions, desig...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Zhao, Jingjing, Conklin, Daniel J., Guo, Yiru, Zhang, Xiang, Obal, Detlef, Guo, Luping, Jagatheesan, Ganapathy, Katragadda, Kartik, He, Liqing, Yin, Xinmin, Prodhan, Md Aminul Islam, Shah, Jasmit, Hoetker, David, Kumar, Amit, Kumar, Vijay, Wempe, Michael F., Bhatnagar, Aruni, Baba, Shahid P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429021/
https://ncbi.nlm.nih.gov/pubmed/32515247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015222
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