Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice

BACKGROUND: Aortic aneurysms and dissections are highly lethal diseases for which an effective treatment strategy is critically needed to prevent disease progression. The nucleotide‐binding oligomerization domain–like receptor pyrin domain containing 3 (NLRP3)–caspase‐1 inflammasome cascade was rece...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Ren, Pingping, Wu, Darrell, Appel, Richard, Zhang, Lin, Zhang, Chen, Luo, Wei, Robertson, Avril A. B., Cooper, Matthew A., Coselli, Joseph S., Milewicz, Dianna M., Shen, Ying H., LeMaire, Scott A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428617/
https://ncbi.nlm.nih.gov/pubmed/32223388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.014044
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