Oxygen Exposure During Cardiopulmonary Resuscitation Is Associated With Cerebral Oxidative Injury in a Randomized, Blinded, Controlled, Preclinical Trial

BACKGROUND: Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial‐derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during CPR. We hypothesized exposure to 1.0 inspired oxygen during CPR would result in cerebral hypero...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Marquez, Alexandra M., Morgan, Ryan W., Ko, Tiffany, Landis, William P., Hefti, Marco M., Mavroudis, Constantine D., McManus, Meagan J., Karlsson, Michael, Starr, Jonathan, Roberts, Anna L., Lin, Yuxi, Nadkarni, Vinay, Licht, Daniel J., Berg, Robert A., Sutton, Robert M., Kilbaugh, Todd J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428577/
https://ncbi.nlm.nih.gov/pubmed/32321350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015032
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