Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model

OBJECTIVE: Cerebral mitochondrial dysfunction is a key mediator of neurologic injury following cardiac arrest (CA) and is regulated by the balance of fusion and fission (mitochondrial dynamics). Under stress, fission can decrease mitochondrial mass and signal apoptosis, while fusion promotes oxidati...

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Bibliographic Details
Published in:Resusc Plus
Main Authors: Senthil, Kumaran, Morgan, Ryan W., Hefti, Marco M., Karlsson, Michael, Lautz, Andrew J., Mavroudis, Constantine D., Ko, Tiffany, Nadkarni, Vinay M., Ehinger, Johannes, Berg, Robert A., Sutton, Robert M., McGowan, Francis X., Kilbaugh, Todd J.
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Experimental Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244484/
https://ncbi.nlm.nih.gov/pubmed/34223382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resplu.2021.100124
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