Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model

OBJECTIVE: Cerebral mitochondrial dysfunction is a key mediator of neurologic injury following cardiac arrest (CA) and is regulated by the balance of fusion and fission (mitochondrial dynamics). Under stress, fission can decrease mitochondrial mass and signal apoptosis, while fusion promotes oxidati...

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Vydáno v:Resusc Plus
Hlavní autoři: Senthil, Kumaran, Morgan, Ryan W., Hefti, Marco M., Karlsson, Michael, Lautz, Andrew J., Mavroudis, Constantine D., Ko, Tiffany, Nadkarni, Vinay M., Ehinger, Johannes, Berg, Robert A., Sutton, Robert M., McGowan, Francis X., Kilbaugh, Todd J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Experimental Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244484/
https://ncbi.nlm.nih.gov/pubmed/34223382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resplu.2021.100124
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