Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

ZnT8 is a Zn(2+)/H(+) antiporter that belongs to SLC30 family and plays an essential role in regulating Zn(2+) accumulation in the insulin secretory granules of pancreatic β cells. However, the Zn(2+)/H(+) exchange mechanism of ZnT8 remains unclear due to the lack of high-resolution structures. Here...

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Vydáno v:eLife
Hlavní autoři: Xue, Jing, Xie, Tian, Zeng, Weizhong, Jiang, Youxing, Bai, Xiao-chen
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428307/
https://ncbi.nlm.nih.gov/pubmed/32723473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58823
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