BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that deregulated transcript...

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Publicado en:Nat Commun
Autores principales: Lam, Fred C., Kong, Yi Wen, Huang, Qiuying, Vu Han, Tu-Lan, Maffa, Amanda D., Kasper, Ekkehard M., Yaffe, Michael B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428008/
https://ncbi.nlm.nih.gov/pubmed/32796829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17503-y
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