BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that deregulated transcript...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Lam, Fred C., Kong, Yi Wen, Huang, Qiuying, Vu Han, Tu-Lan, Maffa, Amanda D., Kasper, Ekkehard M., Yaffe, Michael B.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428008/
https://ncbi.nlm.nih.gov/pubmed/32796829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17503-y
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