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Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to frequent anaemia and decreased adaptive immunity. How intrinsic changes to the hematopoietic stem cells (HSCs), an altered microenvironment and systemic factors contribute to this process is not fully understood. He...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Valletta, Simona, Thomas, Alexander, Meng, Yiran, Ren, Xiying, Drissen, Roy, Sengül, Hilal, Di Genua, Cristina, Nerlov, Claus
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427787/
https://ncbi.nlm.nih.gov/pubmed/32796847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17942-7
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