C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations...

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Bibliografiske detaljer
Udgivet i:Cancer Cell
Main Authors: Di Genua, Cristina, Valletta, Simona, Buono, Mario, Stoilova, Bilyana, Sweeney, Connor, Rodriguez-Meira, Alba, Grover, Amit, Drissen, Roy, Meng, Yiran, Beveridge, Ryan, Aboukhalil, Zahra, Karamitros, Dimitris, Belderbos, Mirjam E., Bystrykh, Leonid, Thongjuea, Supat, Vyas, Paresh, Nerlov, Claus
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218711/
https://ncbi.nlm.nih.gov/pubmed/32330454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.03.022
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