C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Di Genua, Cristina, Valletta, Simona, Buono, Mario, Stoilova, Bilyana, Sweeney, Connor, Rodriguez-Meira, Alba, Grover, Amit, Drissen, Roy, Meng, Yiran, Beveridge, Ryan, Aboukhalil, Zahra, Karamitros, Dimitris, Belderbos, Mirjam E., Bystrykh, Leonid, Thongjuea, Supat, Vyas, Paresh, Nerlov, Claus
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218711/
https://ncbi.nlm.nih.gov/pubmed/32330454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.03.022
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