Novel mannopyranoside esters as sterol 14α-demethylase inhibitors: Synthesis, PASS predication, molecular docking, and pharmacokinetic studies

Direct unimolar one-step valeroylation of methyl α-d-mannopyranoside (MDM) furnished mainly 6-O-valeroate. However, similar reaction catalyzed by DMAP resulted 3,6-di-O-valeroate (21%) and 6-O-valeroate (47%) indicating reactivity sequence as 6-OH>3-OH>2-OH,4-OH. To get potential antimicrobial...

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Bibliographic Details
Published in:Carbohydr Res
Main Authors: Matin, Mohammed M., Chakraborty, Priyanka, Alam, Muhammad S., Islam, Mohammad M., Hanee, Umme
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427576/
https://ncbi.nlm.nih.gov/pubmed/32863019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2020.108130
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