Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma

Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a network of proteins, including NOTCH1, via degradation. In this study, we first described the...

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Publicat a:Cell Death Dis
Autors principals: Zheng, Yang, Song, An, Wang, Chundi, Zhang, Wei, Liang, Dong, Ding, Xu, Li, Gang, Zhang, Hongchuang, Du, Yifei, Zhou, Junbo, Wu, Heming, Wu, Yunong, Song, Xiaomeng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426429/
https://ncbi.nlm.nih.gov/pubmed/32792479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02873-4
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